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Nirva Institute · Astrocytes · Mental Health & Experience

Astrocytes and Cognitive Flexibility

The ability to update behavior when the world changes.

The Nirva InstitutePublished 20265 min read
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Cognitive flexibility — the ability to switch strategies when conditions change — depends on prefrontal circuits and monoaminergic modulation. Astrocytes contribute at multiple levels.

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A network property

Astrocyte manipulation can influence attention, learning, and behavioral switching in animal models.196,195



Scientific References

Primary literature

AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.

  1. 195.Adamsky A, Kol A, Kreisel T, et al. Astrocytic activation generates de novo neuronal potentiation and memory enhancement. Cell. 2018;174(1):59-71. PubMed ↗
  2. 196.Nagai J, Rajbhandari AK, Gangwani MR, et al. Hyperactivity with disrupted attention by activation of an astrocyte synaptogenic cue. Cell. 2019;177(5):1280-1292. PubMed ↗

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