Nirva Institute · Astrocytes · Mental Health & Experience
Astrocytes and Anxiety Disorders
A biology of persistent activation.
Anxiety disorders involve sustained physiological activation and altered fear-related learning. Preclinical work has begun to identify astrocyte contributions to these processes.
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Preclinical evidence
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Distance to the clinic
Human evidence is still limited. Anxiety disorders are complex, and astrocyte findings are one thread of a larger biological picture.
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 196.Nagai J, Rajbhandari AK, Gangwani MR, et al. Hyperactivity with disrupted attention by activation of an astrocyte synaptogenic cue. Cell. 2019;177(5):1280-1292. PubMed ↗
- 208.Cao X, Li LP, Wang Q, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med. 2013;19(6):773-777. PubMed ↗
- 209.Bang J, Kim HY, Lee H. Optogenetic and chemogenetic approaches for studying astrocytes and gliotransmitters. Exp Neurobiol. 2016;25(5):205-221. PubMed ↗
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