Nirva Institute · Astrocytes · Disease & Medicine
Astrocytes in Alzheimer’s Disease
Beyond amyloid: astrocyte responses in an aging brain.
Alzheimer’s disease has long been described in terms of amyloid plaques and tau tangles. Astrocyte biology is increasingly recognized as a co-participant in the disease process.
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Astrocyte responses in Alzheimer’s
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Glymphatic implications
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Emerging targets
Whether astrocyte-targeted therapies can complement amyloid- and tau-focused treatments is an active area of investigation.
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 189.Liddelow SA, Guttenplan KA, Clarke LE, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481-487. PubMed ↗
- 192.Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid-β. Sci Transl Med. 2012;4(147):147ra111. PubMed ↗
- 194.Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016-1024. PubMed ↗
- 199.Verkhratsky A, Rodrigues JJ, Pivoriunas A, Zorec R, Semyanov A. Astroglial atrophy in Alzheimer’s disease. Pflugers Arch. 2019;471(10):1247-1261. PubMed ↗
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