Nirva Institute · Astrocytes · Mental Health & Experience
Astrocytes and Sleep
The glymphatic system and the case for restorative rest.
Sleep serves multiple functions. Astrocyte-dependent processes — particularly glymphatic clearance — are among the most striking findings of the last decade.
§ 1
Glymphatic clearance during sleep
§ 2
Astrocytic sleep regulation
Astrocytes also contribute to sleep homeostasis and to the cognitive consequences of sleep loss.210
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 192.Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid-β. Sci Transl Med. 2012;4(147):147ra111. PubMed ↗
- 193.Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377. PubMed ↗
- 194.Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016-1024. PubMed ↗
- 210.Halassa MM, Florian C, Fellin T, et al. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron. 2009;61(2):213-219. PubMed ↗
Continue Exploring
Library
Astrocytes in Alzheimer’s Disease
Beyond amyloid: astrocyte responses in an aging brain.
ReadLibrary
Astrocytes and Longevity Research
Aging brains and the changing glial environment.
ReadLibrary
The Neuroscience of Body-First Change
Interoception, predictive processing, and the ascending pathways.
Read