Nirva Institute · Astrocytes · Disease & Medicine
Astrocytes and Stroke Recovery
Both protectors and complications after ischemia.
After stroke, astrocytes participate in containment of injury, regulation of inflammation, and the formation of the glial scar. The same cells may support recovery and, in some phases, constrain it.
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Acute response
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Long-term consequences
The glial scar can also impede axonal regrowth, and astrocyte-targeted strategies aim to shift the balance toward repair.202
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 189.Liddelow SA, Guttenplan KA, Clarke LE, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541(7638):481-487. PubMed ↗
- 190.Escartin C, Galea E, Lakatos A, et al. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021;24(3):312-325. PubMed ↗
- 202.Liu Z, Chopp M. Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Prog Neurobiol. 2016;144:103-120. PubMed ↗
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