Nirva Institute · Astrocytes · Disease & Medicine
Astrocytes and Migraine
Cortical spreading depression and astrocyte biology.
Migraine, particularly with aura, is associated with cortical spreading depression — a wave of depolarisation across the cortex that involves both neurons and astrocytes.
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Cortical spreading depression
Cortical spreading depression involves large ionic and neurotransmitter fluxes managed in part by astrocytes.205
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Neurovascular coupling
Astrocyte regulation of local blood flow is a component of the neurovascular changes seen in migraine.
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 205.Charles A, Brennan KC. Cortical spreading depression—new insights and persistent questions. Cephalalgia. 2009;29(10):1115-1124. PubMed ↗
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