Nirva Institute · Astrocytes · Communication & Networks
Astrocytes and GABA Signaling
The inhibitory counterweight.
GABA is the primary inhibitory neurotransmitter in the mature central nervous system. Astrocytes contribute to its uptake, metabolism, and — in specific contexts — release.
§ 1
Astrocytes in the GABA cycle
Astrocytes participate in GABA uptake and metabolism through GAT-3 transporters and glutamine synthesis.182
§ 2
Astrocytic GABA release
Under certain conditions, astrocytes can release GABA and thereby influence local inhibitory tone.185
Scientific References
Primary literature
AMA numeric style. Citation numbers are unified across the Nirva Life ecosystem — the same number refers to the same reference across every library article. Full registry is anchored in the Cornerstone Paper.
- 182.Verkhratsky A, Nedergaard M. Physiology of astroglia. Physiol Rev. 2018;98(1):239-389. PubMed ↗
- 185.Araque A, Carmignoto G, Haydon PG, Oliet SHR, Robitaille R, Volterra A. Gliotransmitters travel in time and space. Neuron. 2014;81(4):728-739. PubMed ↗
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