Definition
Exercise has a dose-dependent relationship with inflammation. Regular, moderate activity is anti-inflammatory overall; extreme or unaccustomed loads can transiently elevate inflammatory markers.
Why it matters
Exercise is one of the strongest modifiable inputs into inflammatory tone. Getting the dose right matters.
The Science
Contracting muscle releases myokines (e.g., IL-6 acting in a paradoxically anti-inflammatory pattern when acutely released from muscle), which influence metabolism, immunity, and mood. Regular activity is associated with lower resting inflammatory markers, better vaccine response, and lower risk of chronic inflammatory disease.
The NSI Perspective
NSI holds movement as one of the primary inputs to a well-regulated immune system.
Clinical Implications
Prescriptive movement — tailored, paced, and repeatable — is a legitimate immune intervention, especially in chronic conditions.
Practical Application
You do not need punishing workouts. You need consistent movement your nervous and immune systems can trust.
References
- 1.Pedersen BK. Muscle as a secretory organ. Compr Physiol. 2013;3(3):1337–1362.